Smallpox remains the only human disease that has been successfully eradicated. Its scourge has been global, impacting nearly every great civilization from the time of the Pharaohs onward.

In Europe, it reportedly claimed 60 million lives in the 1700s. In the 1500s, up to 3 million Aztecs died after being infected by the conquering Spanish, bringing about the collapse of their culture and civilization more effectively than the violent conquistadores could have ever dreamed. The last reported case occurred in the 1970s. Since that time, the virus has existed only in two highly guarded labs.

Smallpox is also tragically rooted in the meeting of European and Native American cultures, and its horrific impact on the continent’s first peoples underlies the nation’s historic narrative as much as political and economic developments from colonial expansion to industrialization to slavery.

The pilgrims, like the Spanish, brought the dreaded scourge, which immediately took a toll on Native tribes on the Eastern seaboard. The first outbreak claimed 20 of the white settlers’ lives. Founding Father Ben Franklin lost a son to smallpox in 1736. But smallpox more than any army, particularly in the Pacific Northwest in the Oregon territory, made it possible for the young American nation to conquer Native areas, many totally wiped clean of their Native inhabitants. I will talk more about the impacts in Oregon shortly, but first some background on the killer virus.

Smallpox’s enormous role in North American and Native American history

There are two smallpox variants, Variola major, the more severe form, and the less severe Variola minor. Its symptoms include fever and lethargy about two weeks after exposure, followed by a sore throat and vomiting. For those afflicted, a rash would then appear on the face and body, and sores in the mouth, throat, and nose. Infectious pustules would emerge and expand. By the third week, scabs formed and separated from the skin. The virus is spread by respiratory droplets, and also by contaminated bedding and clothes. This was how many historians suspect the disease may have been transmitted to Native Americans in North America.

French Jesuits in Canada in 1625, according to an account by Ian and Jennifer Glynn in The Life and Death of Smallpox, received great hostility from Natives because of the link made between the disease and contact with Europeans. The missionaries reported the local people “observed with some sort of reason that since our arrival in these lands those who had been the nearest to us had happened to be the most ruined by [smallpox], and that whole village of those who had receive us now appeared utterly exterminated.”

The first recorded use of smallpox as a weapon was during the siege of Fort Pitt in 1763, when Native tribes during Pontiac’s uprising during the French and Indian war were reportedly given infected blankets by a British general, possibly with the goal of infection, even though scientific knowledge at the time did not fully understand germ theory or microbial infections. However, there was an understanding of how the disease might be spread based on experiences.  Reports also exist of the British attempting to infect colonial areas during the Revolutionary War–all early cases of germ warfare.

Smallpox was reportedly used against the 10,000-man contingent of the Continental Army that invaded British-held Quebec. Of that force, half were stricken by smallpox, and it was theorized the British commander may have intentionally spread it by sending infected persons to Continental Army camps. That army’s commander died, and the force retreated in 1776, keeping the Canadian territories intact and thus giving birth to Canada. Noted John Adams, “Our misfortunes in Canada are enough to melt the heart of stone. The smallpox is 10 times more terrible than the British, Canadians and Indians together.”

Abraham Lincoln supposedly contracted it during the height of the Civil Ware in 1863—the outcome of which could have turned the course of U.S. and global history, had he died. (I for one am glad he survived this.)

The first vaccine, developed in 1770, was derived from cowpox by Edward Jenner. He had observed how a milk maid  was inoculated from the impacts of the more deadline Variola major and minor by a previous exposure to cowpox. It was not until 1947 when a frozen vaccine was introduced globally. After a costly global campaign, smallpox was declared eradicated in 1980.

The College of Physicians of Philadelphia has published an extremely useful illustration and timeline of the history of smallpox in the United states and globally.

Today, many people in the United States, particularly those born after routine smallpox vaccinations were ended in 1972, have no memory of how awful such a disease can be. (The CDC has a plan to vaccinate the entire country should the virus ever break free from its labs.)

This may be a contributing factor to the rise of the anti-vaccination movement. It should noted opposition to smallpox vaccination in the United States dates to the 1920s, and opposition even as far back as the first vaccine of Jenners.

Ex-Playmate McCarthy and the vaccination deniers

The most famous case of modern day vaccination denialism is linked to controversies surrounding the measles, mumps, and rubella (MMR) vaccine, and its alleged link to autism and autism spectrum disorder. This bogus claim was completely based on a widely discredited study published by the British medical journal the Lancet in 2004, and then formally retracted in 2010. It was further debunked by extensive population based studies.

Facts, of course, have still not stopped former 1994 Playmate of the year Jenny McCarthy, and the “Green our Vaccines” campaign, from claiming toxins in vaccines cause autism.

Her campaign of disinformation just got a boost when she was given a national stage by Walt Disney Co.-owned ABC News, which hired the vaccination extremist to its show called The View in mid-July 2013. She begins her post in September.

As expected a chorus of worried public health advocates and policy wonks decried ABC’s crass capitalistic gesture. This made no impact whatsoever on the parent corporation, Disney—all of which might lead a rational person to ask when the Disney-owned ABC News might hire a blond, big-boobed Holocaust denier to co-host a lively, unscripted talk show, so long as she boosted ratings.

Smallpox wiped out Native Americans in state that now has the highest rates of vaccination exemptions

It seems particularly and painfully ironic that the state with the highest rate of parents opting out of childhood vaccinations is Oregon. This is a major public health concern, because when there are fewer people receiving vaccinations, herd immunity is reduced, making it easier for a disease to spread.

Oregon currently has the highest rate of unvaccinated children in the nation, well above the national average of 1.2%.

As of 2013, Oregon schools had the highest rate of non-medical–meaning religious–immunization exemptions for kindergarten age children. An all time high of 6.4% were exempt. That same year the state also recorded the highest rates for pertussis (whooping cough) cases in the United States, for the past 50 years, according to the Centers for Disease Control and Prevention (CDC).

According to the newsletter called the Lund Report: “In 2013, rates also showed that 17 counties have now surpassed the common 6 percent threshold whereby herd immunity may be compromised for some vaccine-preventable diseases such as pertussis and measles. In 2012, 13 counties were above 6 percent.”

Thanks to a new law signed in July 2013 by Gov. John Kitzhaber (D), himself a doctor, it will now be harder for Oregon parents to get exemptions from mandatory immunizations for children enrolling in schools.

Now, flash back more than two centuries, when the scourge of smallpox was first recorded in the Northwest due to trade with Europeans. A smallpox epidemic, starting in the upper Missouri River country, swept through current day Oregon to the Pacific Ocean in 1781–82 with horrific effects. Another scourge of “fever and ague,” likely malaria, ravaged Oregon in 1830–31. Other diseases as tuberculosis, measles, and venereal infections also took a huge toll. Epidemics in fact took an estimated nine of 10 lives of the lower Columbia Indian population between 1830 and 1834.

In 1834, Dr. John Townsend, in the area that would become the Oregon Territory, wrote of a mass extermination of Native residents, similar in scope to what one today only knows through zombie or science fiction films of recent years like World War Z and I am Legend.

Townsend wrote: “The Indians of the Columbia were once a numerous and powerful people; the shore of the river, for scores of miles, was lined with their villages; the council fire was frequently lighted, the pipe passed round, and the destinies of the nation deliberated upon . . . Now alas! where is he? –gone; —gathered to his fathers and to his happy hunting grounds; his place knows him no more. The spot where once stood the thickly peopled village, the smoke curling and wreathing above the closely packed lodges, the lively children playing in the front, and their indolent parents lounging on their mats, is now only indicated by a heap of undistinguishable ruins. The depopulation here has been truly fearful. A gentleman told me, that only four years ago, as he wandered near what had formerly been a thickly peopled village, he counted no less than sixteen dead, men and women, lying unburied and festering in the sun in front of their habitations. Within the houses all were sick; not one had escaped the contagion; upwards of a hundred individuals, men, women, and children, were writhing in agony on the floors of the houses, with no one to render them any assistance. Some were in the dying struggle, and clenching with the convulsive grasp of death their disease-worn companions, shrieked and howled in the last sharp agony.”

While stationed in Fort Vancouver on the banks of the Columbia River in 1852 and 1853, future Union General and President Ulysses S. Grant recorded similar devastation: “The Indians, along the lower Columbia as far as the Cascades and on the lower Willamette, died off very fast during the year I spent in that section; for besides acquiring the vices of the white people they had acquired also their diseases. The measles and the small-pox were both amazingly fatal. … During my year on the Columbia River, the smallpox exterminated one small remnant of a band of Indians entirely, and reduced others materially. I do not think there was a case of recovery among them, until the doctor with the Hudson Bay Company took the matter in hand and established a hospital. Nearly every case he treated recovered. I never, myself, saw the treatment described in the preceding paragraph, but have heard it described by persons who have witnessed it. The decimation among the Indians I knew of personally, and the hospital, established for their benefit, was a Hudson’s Bay building not a stone’s throw from my own quarters.”

(For those interested in this topic, they may wish to buy, download, or borrow a study of smallpox’s impact on Native North Americans called Rotting Face: Smallpox and the American Indian. One reviewer wrote that smallpox “claimed more lives from the Northern Plains tribes in one year than all the military expeditions ever sent against American Indians.”)

Where is the statue or monument pointing out this critical event in Oregon’s history?

Yet, I could find no record of any statue or memorial in Oregon today that notes this historic tragedy, which depopulated a region and left it wide open for white settlers to inhabit in the mid-1800s. Perhaps if such physical reminders were present, and educational programs to accompany them, there might be a more lively debate in Oregon. But as of now, it is state celebrated for its vaccination deniers and for denying the benefits of community water fluoridation for residents of its major urban center, Portland, for a fourth time since the 1950s.

Maybe a statue honoring ghost villages, dead tribes, and forgotten cultures on the banks of scenic Multnomah River in downtown Portland, could kick off with a special celebrity ceremony. The organizers could host a live broadcast of The View with Jenny McCarthy, in a revealing dress, describing why the state’s residents should keep their children from getting vaccinated from diseases such as pertussis.

I would be sure this event included representatives of the remaining tribal groups who managed to survive the wholesale disease-driven extermination of their brethren not many decades ago, many due to illnesses now controlled through childhood immunizations. Now that would be an attention-grabbing event that might just propel the discussion in a new direction.